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The authors noted that the association between RLS and erectile dysfunction also could be related in part to other sleep disorders that co-occur with RLS. For example, obstructive sleep apnea and sleep deprivation may decrease circulating testosterone levels.
Explain your medical condition in a clear and truthful way. Your doctor can give you literature on the condition for you to share with your partner.
"If you're a man who needs Viagra on your 30's or 40's," Adams added, "you don't need Viagra, you need to clean up your diet and start exercising!"
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The cyclic nucleotide phosphodiesterases (PDEs1) described in this review are a family of related phosphohydrolases that selectively catalyze the hydrolysis of the 3? cyclic phosphate bonds of adenosine and/or guanosine 3?,5? cyclic monophosphate. The structure of cAMP and the bond hydrolyzed is shown in Fig. 1. These enzymes are often referred to as class I cyclic nucleotide PDEs to differentiate them from class II enzymes. Class II enzymes are found in many species including mammals and will also catalyze the hydrolysis of the phosphodiester bond. However, in general, the Class II enzymes do not show the same substrate selectivity as the class I enzymes and much more is known about the class I enzymes.
Health professionals aren't sure what causes premenstrual syndrome, but the likely cause is the fluctuation of two hormones, estrogen and progesterone. Estrogen may affect feel-good hormones endorphins and serotonin, contributing to depression, irritability and anger.
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Research into the structure, function, and regulation of PDEs has progressed a long way from the initial identification of PDE activity nearly 50 years ago. The PDE enzymes are now well recognized to be important regulators of many different cellular functions. Research in the field has evolved from early studies primarily concerning identification of PDE enzymes and characterization of their kinetic and regulatory properties to more recent work on their structure and how their activities are regulated in the cellular context. This accumulation of basic knowledge should further foster the targeting of these enzymes for drug development and clinical treatment.
The researchers at the Chinese University of Hong Kong believe that the root cause of both the erectile problems and the heart disease could be down to blood vessel damage caused by high blood sugar levels. They advise men who have impotency problems to see their doctor, as this appears to be a reliable warning sign of future health problems.
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